Moracin C

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Moracin C，一种天然产物，是一种抗炎剂。Moracin C 抑制 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO) 从细胞中释放。

Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells.

RT-PCR Cell Line:RAW 264.7 macrophages Concentration:1, 10, 25, 50 μM Incubation Time:2 h Result:Inhibited LPS-induced mRNA expression of iNOS and COX-2.Western Blot Analysis Cell Line:RAW 264.7 macrophages Concentration:1, 10, 25, 50 μM Incubation Time:2 h Result:Inhibited LPS-induced TLR4 expression and NF-κB activation.Reduced phosphorylated p38, ERK and JNK levels.

Animal Model:Mice (PK Assay)Dosage:100 mg/kg Administration:Oral gavage Result:Pharmacokinetic profile of Moracin C.

——

Immunology/Inflammation

ROS

ROS | NO Synthase

——

——

69120-06-5

310.34

C19H18O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (805.57 mM; 超声助溶 )

CC(C)=CCc1c(O)cc(cc1O)-c1cc2ccc(O)cc2o1

——

(-20℃)

With Ice Pack

≥ 2 years